ALD/ALE 2025 Session AA4-WeA: Medical Applications

The pharmaceutical industry faces persistent challenges in optimizing drug delivery systems, including achieving controlled release, improving drug dispersion in liquid formulations, and enhancing the bioavailability of poorly soluble drugs. Current strategies often involve complex processes that can compromise the stability of active pharmaceutical ingredients (APIs). To address these challenges, we have developed a novel coating process using atmospheric pressure atomic layer deposition (AP-ALD) at room temperature in a fluidized bed reactor. This scalable and chemically benign method tailors the surface properties of pharmaceutical powders. Specifically, we demonstrate that AP-ALD coatings can: (1) prolong the dissolution of pharmaceuticals by up to eightfold for extended-release applications, as demonstrated with metformin and atenolol; (2) prevent sedimentation of hydrophilic drugs, enabling long-term dispersion in liquid formulations, as shown with diclofenac; and (3) enhance the dissolution rate of poorly soluble drugs, improving their bioavailability, as demonstrated with gliclazide. Our findings reveal the transformative potential of AP-ALD in pharmaceutical manufacturing, offering precise control over surface interactions while preserving the chemical integrity of APIs and paving the way for advanced drug delivery systems.

While nanotechnology could play an enormous role in the medical field, it is not straightforward to make nanostructured materials for pharma and medical devices in a scalable manner. We will show that ALD can be used to make nanostructured materials for several health applications in a scalable way.

Modifying the surface of grains of powder – as used, for example, in dry powder inhalers for treating respiratory diseases – can increase the powder flowability while also adding a controlled release functionality. In this way, the powder is used more effectively, and the side effects on the patient can be reduced significantly [1,2].

In targeted radionuclide therapy a major hurdle is the dependence on a very limited number of nuclear reactors worldwide to produce these radioisotopes. ALD can provide a way to prepare radionuclide generators, that can be placed in hospitals, providing on-site and on-demand supply. By modifying sorbent particles for isotope separation by ALD, we have made the first step towards 99Mo/99mTc radionuclide generators [3]. By using Lu ALD on nanoparticles, we have taken a step in producing 177 Lu radionuclides [4].

We also apply ALD to substrates other than powders. Polydimethylsiloxane (PDMS) is a widely used material for lab-on-a-chip and organ-on-a-chip devices. It is very versatile, but the drawback is its low stability, especially when in contact with organic solvents. We will show that modifying the surface with ceramic oxide using ALD is a way to get much more durable microfluidic devices, usable for a range of health applications [5,6].

Summarizing, we can conclude that making nanostructured materials using ALD has a range of applications in the medical field. The combination of nanoprecision and scalability gives it a lot of potential.

References

[1] D. Zhang, D. La Zara, M.J. Quayle, G. Petersson, J.R. van Ommen, S. Folestad, ACS Appl. Bio Mater., 2, 1518 (2019).

[2] D. La Zara, F. Sun, F. Zhang, F. Franek, K. Balogh Sivars, J. Horndahl, S. Bates, M. Brännström, P. Ewing, M.J. Quayle, G. Petersson, S. Folestad, J.R. van Ommen, ACS Nano, 15, 6684 (2021).

[3] J. Moret, J. Alkemade, T.M. Upcraft, E. Oehlke, H.T. Wolterbeek, J.R. van Ommen, A.G. Denkova, Appl. Radiat. Isot., 164, 109266 (2020).

[4] J.L.T.M.Moret, M.B. Griffiths, J.E. Frijns, B.E. Terpstra, H.T. Wolterbeek, S.T. Barry, A.G. Denkova J.R. van Ommen, J. Vac. Sci. Technol. A: Vac. Surf. Films, 38, 022414 (2020).

[5] A. Santoso, M.K. David, P.E. Boukany, V. van Steijn, J.R. van Ommen, Chem. Eng. J., 498, 155269 (2024).

[6] A. Santoso, S. Trapp, I.M. Blommestein, S. Saedy, J.R. van Ommen, R.M. de Kruijff, V. van Steijn, Sep. Purif. Technol., 354, 128865 (2025).