PacSurf2024 Session BI2-TuM: Biomaterials/Interfaces - Biosensing

The forces around us, such as grip forces, loads on buildings and machines, and friction, are closely related to our health and safety. While technologies exist to measure such forces, there are still many types of forces that cannot be measured with existing technologies, such as molecular forces at nanoscale or the detection of curved or anisotropic forces. Mechanochromic materials are expected to play a pivotal role in these niches. In my talk, I will introduce the mechanism and applications of a mechanochromic lipid polymer called polydiacetylene towards biosensing.^1-2

References

1. Juhasz, L.; Ortuso, R. D.; Sugihara, K., Quantitative and Anisotropic Mechanochromism of Polydiacetylene at Nanoscale. Nano Lett 2021, 21 (1), 543-549.

1. Chen, J. L.; Zheng, J. L.; Hou, Y. G.; Sugihara, K., Colorimetric response in polydiacetylene at the single domain level using hyperspectral microscopy. Chem Commun 2023, 59 (25), 3743-3746.

A major issue faced by electrochemical surfaces that need to function in biological fluids remains the biofouling of electrode surfaces. In this presentation, I will demonstrate how lubricin (LUB) can mitigate the biofouling issue and enable the development of biosensors that function in unprocessed whole blood. LUB is a cytoprotective glycoprotein present in synovial fluids and coating cartilage surfaces in articular joints.¹ It displays a distinguishing chemistry, conformational and molecular structure, and also the ability to self-assemble in a well-organized manner on substrates of different materials.^2,3 When attached to a conductive surface, LUB presents the capability of preventing biofouling and at the same time allowing good electrochemistry with the advantage of a simple and one-step coating preparation.⁴ This makes LUB an interesting surface coating for applications such as bionic implants and electrochemical biosensors. In this presentation, I highlight both recent technological advances associated with the LUB coatings for use in electroactive surfaces and a number of recent advances toward point-of-care diagnostics enabled by this unique biomimetic surface coating.

References

[1] S. M. Silva, A. F. Quigley, R. M. I. Kapsa, G. W. Greene, S. E. Moulton, Chemelectrochem 2019, 6, 1939-1943.

[2] M. Y. Han, S. M. Silva, W. W. Lei, A. Quigley, R. M. I. Kapsa, S. E. Moulton, G. W. Greene, Langmuir 2019, 35, 15834-15848.

[3] Silva, S. M.; Langley, D.; Cossins, L.; Samudra, A.; Quigley, A. F.; Kapsa, R. M. I.; Tothill, R. W.; Greene, G. W.; Moulton, S. E. ACS Sensors 2022, 7, 3379–3388.

[4] M. J. Russo, M. Y. Han, A. F. Quigley, R. M. I. Kapsa, S. E. Moulton, E. Doeven, R. Guijt, S. M. Silva, G. W. Greene, Electrochimica Acta 2020, 333.